13 Best Business Hotels in Rochester, MN (2026)

Business Hotels in Rochester, MN: Rates Starting at $57 per Night

Hilton Garden Inn Rochester Downtown
Hotel
225 South Broadway, Rochester, MN 55904, USA
• View on map
  • Private Pool
    Private Pool
  • Hot Tub
    Hot Tub
  • Pool
    Pool
  • Balcony/Terrace
    Balcony/Terrace
1 Baths355.21 ft²
8.4

Exceptional

257 reviews

$196
Average price / night
Check Availability
Comfort Inn & Suites West - Medical Center
Hotel
2005 Commerce Drive, Rochester, MN 55901, USA
• View on map
  • Breakfast
    Breakfast
  • Kitchen
    Kitchen
  • Parking
    Parking
  • Air Conditioner
    Air Conditioner
12 Baths356.87 ft²
8

Exceptional

217 reviews

$103
Average price / night
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Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hotel
401 6th Street Southwest, Rochester, MN 55902, USA
• View on map
  • Private Pool
    Private Pool
  • Oceanfront
    Oceanfront
  • Hot Tub
    Hot Tub
  • Spa
    Spa
2 Baths378.89 ft²
7.8

Exceptional

487 reviews

$137
Average price / night
Check Availability
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Hotel
1517 16th St Sw Rochester, MN 55902, Rochester, 55902-1075, USA
• View on map
  • Private Pool
    Private Pool
  • Oceanfront
    Oceanfront
  • Hot Tub
    Hot Tub
  • Spa
    Spa
1 Baths254.53 ft²
7.8

Exceptional

490 reviews

$121
Average price / night
Check Availability
Kahler Grand Hotel
Hotel
20 Southwest 2nd Avenue, Rochester, MN 55902, USA
• View on map
  • Private Pool
    Private Pool
  • Fireplace/Heating
    Fireplace/Heating
  • Pool
    Pool
  • Breakfast
    Breakfast
1 Baths170.07 ft²
7.5

Exceptional

248 reviews

$154
Average price / night
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Rochester Marriott Mayo Clinic Area
Hotel
101 First Avenue Southwest, Rochester, MN 55902, USA
• View on map
  • Private Pool
    Private Pool
  • Oceanfront
    Oceanfront
  • Hot Tub
    Hot Tub
  • Fireplace/Heating
    Fireplace/Heating
4 Baths365.97 ft²
7.7

Exceptional

77 reviews

$236
Average price / night
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Rochester Marriott Mayo Clinic Area
Hotel
101 First Avenue Southwest, Rochester, MN 55902, USA
• View on map
  • Private Pool
    Private Pool
  • Oceanfront
    Oceanfront
  • Hot Tub
    Hot Tub
  • Fireplace/Heating
    Fireplace/Heating
4 Baths365.97 ft²
7.7

Exceptional

77 reviews

$236
Average price / night
Check Availability
Residence Inn Rochester Mayo Clinic Area
Hotel
441 West Center Street, Rochester, MN 55902, USA
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Balcony/Terrace
    Balcony/Terrace
  • Breakfast
    Breakfast
  • Pet Friendly
    Pet Friendly
2 Baths457.47 ft²
8

Exceptional

22 reviews

$252
Average price / night
Check Availability
La Quinta by Wyndham Rochester Mayo Clinic Area South
Hotel
4353 Canal Place Southeast, Rochester, MN 55904, USA
• View on map
  • Private Pool
    Private Pool
  • Oceanfront
    Oceanfront
  • Fireplace/Heating
    Fireplace/Heating
  • Pool
    Pool
12 Baths333.68 ft²
7.2

Exceptional

499 reviews

$101
Average price / night
Check Availability
Homewood Suites by Hilton Rochester Mayo Clinic-St. Marys Campus
Hotel
165 13th Avenue Southwest, Rochester, MN 55902, USA
• View on map
  • Private Pool
    Private Pool
  • Oceanfront
    Oceanfront
  • Hot Tub
    Hot Tub
  • Spa
    Spa
  • Highly Rated
    Highly Rated
  • Ocean View
1 Baths731.94 ft²
9

Exceptional

60 reviews

$137
Average price / night
Check Availability
MainStay Suites Rochester South Mayo Clinic
Hotel
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Breakfast
    Breakfast
  • Pet Friendly
    Pet Friendly
  • Parking
    Parking
1 Baths301.39 ft²
7.1

Exceptional

114 reviews

$57
Average price / night
Check Availability
Staybridge Suites Rochester by IHG
Hotel
2350 Commerce Drive Northwest, Rochester, MN 55901, USA
• View on map
  • Private Pool
    Private Pool
  • Hot Tub
    Hot Tub
  • Fireplace/Heating
    Fireplace/Heating
  • Pool
    Pool
8 Baths322.92 ft²
8.1

Exceptional

70 reviews

$166
Average price / night
Check Availability
SpringHill Suites Rochester Mayo Clinic Area/Saint Marys
Hotel
1125 2nd Street Southwest, Rochester, MN 55902, USA
• View on map
  • Private Pool
    Private Pool
  • Hot Tub
    Hot Tub
  • Fireplace/Heating
    Fireplace/Heating
  • Pool
    Pool
1 Baths
8.4

Exceptional

202 reviews

$122
Average price / night
Check Availability

Compare the 13 Best Business Hotels in Rochester, MN (2026) – Addresses, Prices, Stars, Rating, and Review Count

Hotel Name Address Price ($)Star Rating Review Count Book
Hilton Garden Inn Rochester Downtown225 South Broadway, Rochester, MN 55904, USA19638.4257
Comfort Inn & Suites West - Medical Center2005 Commerce Drive, Rochester, MN 55901, USA10348217
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area401 6th Street Southwest, Rochester, MN 55902, USA13747.8487
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's1517 16th St Sw Rochester, MN 55902, Rochester, 55902-1075, USA12137.8490
Kahler Grand Hotel20 Southwest 2nd Avenue, Rochester, MN 55902, USA15437.5248
Rochester Marriott Mayo Clinic Area101 First Avenue Southwest, Rochester, MN 55902, USA23637.777
Rochester Marriott Mayo Clinic Area101 First Avenue Southwest, Rochester, MN 55902, USA23637.777
Residence Inn Rochester Mayo Clinic Area441 West Center Street, Rochester, MN 55902, USA2523822
La Quinta by Wyndham Rochester Mayo Clinic Area South4353 Canal Place Southeast, Rochester, MN 55904, USA10137.2499
Homewood Suites by Hilton Rochester Mayo Clinic-St. Marys Campus165 13th Avenue Southwest, Rochester, MN 55902, USA1373960
Staybridge Suites Rochester by IHG2350 Commerce Drive Northwest, Rochester, MN 55901, USA16638.170
SpringHill Suites Rochester Mayo Clinic Area/Saint Marys1125 2nd Street Southwest, Rochester, MN 55902, USA12238.4202

Note: The prices for each 13 Best Business Hotels in Rochester, MN (2026) do vary. This can be because of the number of people you are booking for, how far in advance you book and the season. The prices above are only meant as a rough estimate for comparison purposes. Click the buttons above (or click here>) to get the latest prices.

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