7 Best Central Hotels in San Diego (2026)

Central Hotels in San Diego: Prices Start at $251 per Night

Andaz San Diego, By Hyatt
Hotel
600 F Street, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Oceanfront
    Oceanfront
  • Fireplace/Heating
    Fireplace/Heating
  • Pool
    Pool
  • Ocean View
    Ocean View
11 Baths570.49 ft²
7.6

Exceptional

126 reviews

$458
Average price / night
Check Availability
Hotel Republic San Diego, Autograph Collection
Hotel
421 West B Street, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Balcony/Terrace
    Balcony/Terrace
  • Pet Friendly
    Pet Friendly
  • Kitchen
    Kitchen
7 Baths396.72 ft²
8.2

Exceptional

331 reviews

$352
Average price / night
Check Availability
The Guild Hotel, San Diego Downtown, a Tribute Portfolio Hotel
Hotel
500 West Broadway, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Balcony/Terrace
    Balcony/Terrace
  • View
    View
  • Breakfast
    Breakfast
14 Baths411.51 ft²
8.2

Exceptional

936 reviews

$252
Average price / night
Check Availability
Hotel Indigo San Diego - Gaslamp Quarter by IHG
Hotel
509 9th Avenue, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Balcony/Terrace
    Balcony/Terrace
  • Breakfast
    Breakfast
  • Pet Friendly
    Pet Friendly
15 Baths479.35 ft²
8.3

Exceptional

472 reviews

$285
Average price / night
Check Availability
The US Grant, a Luxury Collection Hotel, San Diego
Hotel
326 Broadway, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Breakfast
    Breakfast
  • Pet Friendly
    Pet Friendly
  • Kitchen
    Kitchen
15 Baths381.84 ft²
8.1

Exceptional

113 reviews

$636
Average price / night
Check Availability
Horton Grand Hotel
Hotel
311 Island Avenue, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Fireplace/Heating
    Fireplace/Heating
  • Balcony/Terrace
    Balcony/Terrace
  • Breakfast
    Breakfast
  • Pet Friendly
    Pet Friendly
  • Price Dropped
    Price Dropped
  • Free Cancellation
5 Baths372.43 ft²
8.5

Exceptional

1605 reviews

$251
Average price / night
Check Availability
Alma San Diego Downtown, a Tribute Portfolio Hotel
Hotel
1047 5th Avenue, Downtown San Diego, San Diego, CA 92101, USA
• View on map
  • Oceanfront
    Oceanfront
  • Fireplace/Heating
    Fireplace/Heating
  • Pool
    Pool
  • Ocean View
    Ocean View
18 Baths589.71 ft²
8.2

Exceptional

739 reviews

$337
Average price / night
Check Availability

Compare the 7 Best Central Hotels in San Diego (2026) – Addresses, Prices, Stars, Rating, and Review Count

Hotel Name Address Price ($)Star Rating Review Count Book
Andaz San Diego, By Hyatt600 F Street, Downtown San Diego, San Diego, CA 92101, USA45857.6126
Hotel Republic San Diego, Autograph Collection421 West B Street, Downtown San Diego, San Diego, CA 92101, USA35248.2331
The Guild Hotel, San Diego Downtown, a Tribute Portfolio Hotel500 West Broadway, Downtown San Diego, San Diego, CA 92101, USA25248.2936
Hotel Indigo San Diego - Gaslamp Quarter by IHG509 9th Avenue, Downtown San Diego, San Diego, CA 92101, USA28548.3472
The US Grant, a Luxury Collection Hotel, San Diego326 Broadway, Downtown San Diego, San Diego, CA 92101, USA63658.1113
Horton Grand Hotel311 Island Avenue, Downtown San Diego, San Diego, CA 92101, USA25148.51605
Alma San Diego Downtown, a Tribute Portfolio Hotel1047 5th Avenue, Downtown San Diego, San Diego, CA 92101, USA33748.2739

Note: The prices for each 7 Best Central Hotels in San Diego (2026) do vary. This can be because of the number of people you are booking for, how far in advance you book and the season. The prices above are only meant as a rough estimate for comparison purposes. Click the buttons above (or click here>) to get the latest prices.

7 Best Central Hotels in San Diego (2026) on the Map

refinedluxuryhotels.com logo
About
Nearby destinations
Popular destinations