Where to Stay in St. Louis, MO: Best Business Hotels

St. Louis, MO, a vibrant city known for its rich history and cultural landmarks, offers travelers an enticing blend of attractions, from the iconic Gateway Arch to its lively arts scene and mouthwatering culinary delights. Whether you're exploring the historic neighborhoods or enjoying a night out in the bustling downtown area, St. Louis is sure to captivate your senses.

For business travelers, selecting the right hotel can significantly enhance your experience, providing essential amenities like meeting spaces and convenient locations. In this guide, we’ll explore the best places to stay, nearby neighborhoods, top attractions, and helpful travel tips to ensure your visit to St. Louis is both productive and enjoyable.

In a hurry? Here's our recommended accommodation

Category Recommended accommodation
5 star / luxury
The Ritz-Carlton, St. Louis
Four Seasons St. Louis
4 star hotels
21c Museum Hotel St Louis
Live! by Loews - St. Louis
The Moonrise Hotel

Find Hotels, Resorts, and Rentals Nearby in these Cities & Neighborhoods

Recommended accommodation

21c Museum Hotel St Louis
21c Museum Hotel St Louis
Hotel
Saint Louis, MO, USA

Cheap, Accommodations, Pools, Parking, Spa, Gites, Pet-friendly, 4-star, Gostinicies, Rooms, Alberghi, Lodgings, Hot tubs, Places to stay, Family, Accessible hotels

Live! by Loews - St. Louis
Live! by Loews - St. Louis
Hotel
Saint Louis, MO, USA

Luxury, Cheap, Accommodations, Parking, Gites, Pet-friendly, 4-star, Gostinicies, Rooms, Alberghi, Lodgings, Places to stay, Accessible hotels

The Moonrise Hotel
The Moonrise Hotel
Hotel
Saint Louis, MO, USA

Cheap, Accommodations, Parking, Romantic, Boutique, Gites, Pet-friendly, 4-star, Gostinicies, Rooms, Alberghi, Lodgings, Places to stay, Accessible hotels

The Royal Sonesta Chase Park Plaza St Louis
The Royal Sonesta Chase Park Plaza St Louis
Hotel
Saint Louis, MO, USA

Accommodations, Pools, Parking, Romantic, Gites, Pet-friendly, 4-star, Gostinicies, Rooms, Alberghi, Lodgings, Places to stay, Family, Accessible hotels

Hotel Saint Louis, Autograph Collection
Hotel Saint Louis, Autograph Collection
Hotel
Saint Louis, MO, USA

Accommodations, Pools, Parking, Spa, Gites, Pet-friendly, 4-star, Gostinicies, Rooms, Alberghi, Lodgings, Places to stay, Family, Accessible hotels

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Things to do and Activities in St. Louis

🎫 Local Experiences & Attractions in St. Louis, USA

✨ Things to Do

Gateway Arch Riverboat Cruises: Enjoy a scenic cruise along the Mississippi River, offering stunning views of the Gateway Arch and the St. Louis skyline. It's a relaxing way to see the city.

🔗 Check Availability on GetYourGuide

City Museum: Explore this unique museum, where visitors can climb through tunnels, slide down slides, and enjoy art installations made from repurposed materials. A creative haven for all ages.

🔗 Check Availability on GetYourGuide

Cultural Food Tours: Discover St. Louis' culinary scene by joining a guided food tour. Sample local favorites like toasted ravioli and gooey butter cake while learning about the city's history.

🔗 Check Availability on GetYourGuide

📍 Top Attractions

Gateway Arch: The iconic symbol of St. Louis, this 630-foot monument offers tram rides to the top for panoramic views of the city and Mississippi River. Visitor Tip: Arrive early to avoid long lines.

🔗 Book Entry Tickets

Missouri Botanical Garden: This expansive garden features diverse plant collections and beautiful landscapes. Visitors can attend seasonal events and workshops throughout the year.

🔗 Book Entry Tickets

St. Louis Art Museum: Located in Forest Park, this museum houses an impressive collection of art from various cultures and time periods. Admission is free, making it accessible for all.

🔗 Book Entry Tickets

Travel Tips for St. Louis

💡 Essential Logistics & Insider Tips for St. Louis, USA

🚆 Getting Around

The Core Tip: St. Louis is a major city with a well-connected public transportation system, including buses and light rail services (MetroLink) that make navigating the area convenient.

The Pro Move: For the most efficient travel, consider using MetroLink to avoid traffic and parking hassles when visiting popular districts like Downtown or The Loop.

📅 Timing Your Trip

The Core Tip: Summer is typically the busiest travel season, with pleasant weather attracting visitors to outdoor events and attractions like the St. Louis Zoo.

The Pro Move: Early mornings or weekdays are ideal for visiting popular spots, such as the Gateway Arch, to avoid crowds.

🚶 Getting Around Safely

The Core Tip: St. Louis features walkable neighborhoods, especially around attractions like Forest Park and Delmar Loop, making it easy to explore on foot.

The Pro Move: Stay aware of your surroundings and stick to well-lit areas at night for added safety while walking between destinations.

💳 Money & Payments

The Core Tip: Most hotels, restaurants, and attractions in St. Louis accept credit cards, ensuring a smooth payment experience for travelers.

The Pro Move: Carrying small cash may be useful for local markets or street vendors, which might prefer cash transactions.

✈️ Airport / Arrival Tips

The Core Tip: From Lambert-St. Louis International Airport, travelers can use rideshare services, taxis, or a rental car to reach downtown, all conveniently accessible from the airport terminals.

The Pro Move: Familiarize yourself with pickup signage at the airport for quicker access to rideshare options, especially during peak arrival times.

Where to Stay in St. Louis, MO: Best Business Hotels properties on the Map